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The exact mechanism of the phenomenon, termed endotoxin tolerance, is unknown". Also, some scientific studies have demonstrated the endotoxin in the Legionnaires' bacillus has a distinct spectrum of toxicity than the more typical gram-destructive organisms. Especially the Legionnaires' endotoxin wasn't quite pyrogenic (with the rabbit examination), but was really active within the LAL - 1,000 fold distinction between The 2 tests. In this example, the rabbit take a look at is inadequate for figuring out the potency from the toxins existing.
Some suppliers have at times resorted to significantly less acceptable approaches including washing or rinsing the crystal or powder with a solvent in an effort to eliminate endotoxins.}